IgY-technology (egg yolk antibodies) in human medicine: a review of patents and clinical trials

IgY-technology (the production and extraction of specific IgY antibodies from egg yolk) is an innovative method to produce antibodies for therapy and prophylaxis. Advantages of IgY over other antibodies comprise its cost-effective extraction, the minimization of animal harm and distress, and its reduced reactivity with mammalian factors. Many research groups have demonstrated that IgY is active against several pathogens or conditions, a fact that may support the design of novel, safe and effective health products. This review provides a comprehensive analysis of IgY-based biologicals for human medicine, including patent applications and clinical trials during the period 2010–2018, and addresses how IgY-technology can lead to innovation in the production of biologicals for the treatment and prophylaxis of a wide range of infectious and non-communicable diseases.

Bibliographic Details

Main Authors:	Leiva, Carlos, Gallardo, Mauro Julián, Casanova, Natalia Andrea, Terzolo, Horacio, Chacana, Pablo
Format:	info:ar-repo/semantics/artículo biblioteca
Language:	eng
Published:	Elsevier 2020-04
Subjects:	Antibodies, Egg Yolk, Therapy, Patents, Clinical Trials, Medical Sciences, Human Diseases, Anticuerpos, Yema de Huevo, Terapia, Patentes, Ensayos Clínicos, Ciencias Médicas, Enfermedades Humanas, IgY Antibody, Anticuerpo IgY,
Online Access:	http://hdl.handle.net/20.500.12123/6713 https://www.sciencedirect.com/science/article/pii/S1567576919323677 https://doi.org/10.1016/j.intimp.2020.106269
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