Immunopathogenesis of bovine neosporosis throughout gestation

Immunopathogenesis of bovine neosporosis throughout gestation

Tesis para obtener el grado de Doctor of Philosophy, del College of Medicine and Veterinary de University of Edinburgh, 2013.

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Bibliographic Details
Main Author: Canton, German Jose
Other Authors: Smith, Sionagh
Format: info:ar-repo/semantics/tesis doctoral biblioteca
Language:eng
Published: College of Medicine and Veterinary Medicine, University of Edinburgh 2013
Subjects:Patogénesis, Neospora Caninum, Bovina, Gestación, Pathogenesis, Bovinae, Pregnancy,
Online Access:http://hdl.handle.net/20.500.12123/6334
https://era.ed.ac.uk/handle/1842/8798
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spelling oai:localhost:20.500.12123-63342019-11-19T14:31:36Z Immunopathogenesis of bovine neosporosis throughout gestation Canton, German Jose Smith, Sionagh Chianini, Francesca Katzer, Frank Patogénesis Neospora Caninum Bovina Gestación Pathogenesis Bovinae Pregnancy Tesis para obtener el grado de Doctor of Philosophy, del College of Medicine and Veterinary de University of Edinburgh, 2013. Despite Neospora caninum being recognised as a major cause of bovine abortion, its pathogenesis is only partially understood. Evidence of immune mediated placental pathology has been reported as being responsible for compromising pregnancy probably due to an exacerbated Th1 immune response at the maternal-foetal interface. Different clinical outcomes are known to follow experimental infections at different stages of gestation, with foetal death being the most common finding during early gestation infections, and the birth of live congenitally infected calves following infection in mid or late gestation. The aim of the current study was to characterise the placental cellular immune responses and cytokine expression following experimental Neospora infection during pregnancy. Placentomes were collected from cattle experimentally inoculated with the tachyzoites of the Nc-1 strain during early, mid and late gestation. Inflammation in early gestation was generally moderate to severe. Differently in mid gestation, inflammation was mild to moderate and minimal to mild in late gestation. Generally cellular infiltrates were mainly characterised by the presence of CD3+, CD4+ and γδ T-cells; whereas CD8+ and NK cells were less numerous. Macrophages were detected in larger numbers during later time-points after infection. A moderate to severe infiltration of IL-12, IFN-γ and TNF-α expressing cells was observed in the placentas collected in early gestation. This infiltration was more pronounced in the samples of placentome collected from dams carrying a dead foetus or in those that had aborted, compared with mothers carrying live foetuses at the time of sampling. The distribution of the cellular subsets observed in the three studies was similar. However, cellular infiltrates were more severe following infection during the first trimester in comparison to the second and third trimester. Similarly, the infiltration of Th1 cytokine expressing-cells was more severe in early gestation compared with the milder and more minimal infiltrations observed following N. caninum infection in mid and late gestation, respectively. These results may explain the milder clinical outcome observed when animals are infected in later stages of pregnancy. EEA Balcarce Fil: Cantón Germán José. Instituto Nacional de Tecnología Agropecuaria (INTA) Estación Experimental Agropecuaria Balcarce; Argentina 2019-11-19T14:18:28Z 2019-11-19T14:18:28Z 2013 info:ar-repo/semantics/tesis doctoral info:eu-repo/semantics/doctoralThesis info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/6334 https://era.ed.ac.uk/handle/1842/8798 eng info:eu-repo/semantics/openAccess application/pdf College of Medicine and Veterinary Medicine, University of Edinburgh
institution INTA AR
collection DSpace
country Argentina
countrycode AR
component Bibliográfico
access En linea
databasecode dig-inta-ar
tag biblioteca
region America del Sur
libraryname Biblioteca Central del INTA Argentina
language eng
topic Patogénesis
Neospora Caninum
Bovina
Gestación
Pathogenesis
Bovinae
Pregnancy
Patogénesis
Neospora Caninum
Bovina
Gestación
Pathogenesis
Bovinae
Pregnancy
spellingShingle Patogénesis
Neospora Caninum
Bovina
Gestación
Pathogenesis
Bovinae
Pregnancy
Patogénesis
Neospora Caninum
Bovina
Gestación
Pathogenesis
Bovinae
Pregnancy
Canton, German Jose
Immunopathogenesis of bovine neosporosis throughout gestation
description Tesis para obtener el grado de Doctor of Philosophy, del College of Medicine and Veterinary de University of Edinburgh, 2013.
author2 Smith, Sionagh
author_facet Smith, Sionagh
Canton, German Jose
format info:ar-repo/semantics/tesis doctoral
topic_facet Patogénesis
Neospora Caninum
Bovina
Gestación
Pathogenesis
Bovinae
Pregnancy
author Canton, German Jose
author_sort Canton, German Jose
title Immunopathogenesis of bovine neosporosis throughout gestation
title_short Immunopathogenesis of bovine neosporosis throughout gestation
title_full Immunopathogenesis of bovine neosporosis throughout gestation
title_fullStr Immunopathogenesis of bovine neosporosis throughout gestation
title_full_unstemmed Immunopathogenesis of bovine neosporosis throughout gestation
title_sort immunopathogenesis of bovine neosporosis throughout gestation
publisher College of Medicine and Veterinary Medicine, University of Edinburgh
publishDate 2013
url http://hdl.handle.net/20.500.12123/6334
https://era.ed.ac.uk/handle/1842/8798
work_keys_str_mv AT cantongermanjose immunopathogenesisofbovineneosporosisthroughoutgestation
_version_ 1756007633219747841

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