Postnatal pituitary and follicular activation A revisited hypothesis in a sheep model
The importance of postnatal pituitary activation as regards female reproductive development is not yet understood. By taking advantage of the experimental model developed in a previous study, i.e. ewe lambs expressing markedly different ovarian phenotypes at 50 days of age, we designed this study to determine whether differences found in ovarian status during the early prepubertal period are due to different patterns of postnatal pituitary activation, and to assess whether these differences have long lasting effects on subsequent reproductive performance. Results showed that ewe lambs with high antral follicle count (AFC) at 50 days of age had significantly lower plasma FSH concentrations and higher anti-Mullerian hormone (AMH) concentrations during the first 9 weeks of age compared with low AFC ewe lambs (P<0.0001).With a longitudinal experiment we showed that a high AFC in the early prepubertal period is associated with consistently higher AMH concentrations and numbers of antral follicles up to the postpubertal period, and with higher pregnancy rates in the first breeding season. In addition, the effect of age in decreasing AMH concentrations was more marked in the low AFC group. Results of the present study demonstrate that ewe lambs undergo different patterns of postnatal pituitary activation. A high AFC at 50 days of age indicates an advanced phase of ovarian maturation, which was accompanied by constantly higher AMH concentrations up to the postpubertal period, a greater ovarian response to FSH stimulation and by higher pregnancy rates at first mating, as compared with the low AFC group. © 2016 Society for Reproduction and Fertility.
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dig-inia-es-20.500.12792-45512020-12-15T09:46:38Z Postnatal pituitary and follicular activation A revisited hypothesis in a sheep model Torres-Rovira, L. Succu, S. Pasciu, V. Manca, M. E. Gonzalez-Bulnes, A. Leoni, G. G. Pennino, M. G. Spezzigu, A. Gallus, M. Dattena, M. Monniaux, D. Naitana, S. Berlinguer, F. The importance of postnatal pituitary activation as regards female reproductive development is not yet understood. By taking advantage of the experimental model developed in a previous study, i.e. ewe lambs expressing markedly different ovarian phenotypes at 50 days of age, we designed this study to determine whether differences found in ovarian status during the early prepubertal period are due to different patterns of postnatal pituitary activation, and to assess whether these differences have long lasting effects on subsequent reproductive performance. Results showed that ewe lambs with high antral follicle count (AFC) at 50 days of age had significantly lower plasma FSH concentrations and higher anti-Mullerian hormone (AMH) concentrations during the first 9 weeks of age compared with low AFC ewe lambs (P<0.0001).With a longitudinal experiment we showed that a high AFC in the early prepubertal period is associated with consistently higher AMH concentrations and numbers of antral follicles up to the postpubertal period, and with higher pregnancy rates in the first breeding season. In addition, the effect of age in decreasing AMH concentrations was more marked in the low AFC group. Results of the present study demonstrate that ewe lambs undergo different patterns of postnatal pituitary activation. A high AFC at 50 days of age indicates an advanced phase of ovarian maturation, which was accompanied by constantly higher AMH concentrations up to the postpubertal period, a greater ovarian response to FSH stimulation and by higher pregnancy rates at first mating, as compared with the low AFC group. © 2016 Society for Reproduction and Fertility. 2020-10-22T17:24:00Z 2020-10-22T17:24:00Z 2016 journal article http://hdl.handle.net/20.500.12792/4551 10.1530/REP-15-0316 eng Attribution-NonCommercial-ShareAlike 4.0 International http://creativecommons.org/licenses/by-nc-sa/4.0/ open access |
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The importance of postnatal pituitary activation as regards female reproductive development is not yet understood. By taking advantage of the experimental model developed in a previous study, i.e. ewe lambs expressing markedly different ovarian phenotypes at 50 days of age, we designed this study to determine whether differences found in ovarian status during the early prepubertal period are due to different patterns of postnatal pituitary activation, and to assess whether these differences have long lasting effects on subsequent reproductive performance. Results showed that ewe lambs with high antral follicle count (AFC) at 50 days of age had significantly lower plasma FSH concentrations and higher anti-Mullerian hormone (AMH) concentrations during the first 9 weeks of age compared with low AFC ewe lambs (P<0.0001).With a longitudinal experiment we showed that a high AFC in the early prepubertal period is associated with consistently higher AMH concentrations and numbers of antral follicles up to the postpubertal period, and with higher pregnancy rates in the first breeding season. In addition, the effect of age in decreasing AMH concentrations was more marked in the low AFC group. Results of the present study demonstrate that ewe lambs undergo different patterns of postnatal pituitary activation. A high AFC at 50 days of age indicates an advanced phase of ovarian maturation, which was accompanied by constantly higher AMH concentrations up to the postpubertal period, a greater ovarian response to FSH stimulation and by higher pregnancy rates at first mating, as compared with the low AFC group. © 2016 Society for Reproduction and Fertility. |
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journal article |
author |
Torres-Rovira, L. Succu, S. Pasciu, V. Manca, M. E. Gonzalez-Bulnes, A. Leoni, G. G. Pennino, M. G. Spezzigu, A. Gallus, M. Dattena, M. Monniaux, D. Naitana, S. Berlinguer, F. |
spellingShingle |
Torres-Rovira, L. Succu, S. Pasciu, V. Manca, M. E. Gonzalez-Bulnes, A. Leoni, G. G. Pennino, M. G. Spezzigu, A. Gallus, M. Dattena, M. Monniaux, D. Naitana, S. Berlinguer, F. Postnatal pituitary and follicular activation A revisited hypothesis in a sheep model |
author_facet |
Torres-Rovira, L. Succu, S. Pasciu, V. Manca, M. E. Gonzalez-Bulnes, A. Leoni, G. G. Pennino, M. G. Spezzigu, A. Gallus, M. Dattena, M. Monniaux, D. Naitana, S. Berlinguer, F. |
author_sort |
Torres-Rovira, L. |
title |
Postnatal pituitary and follicular activation A revisited hypothesis in a sheep model |
title_short |
Postnatal pituitary and follicular activation A revisited hypothesis in a sheep model |
title_full |
Postnatal pituitary and follicular activation A revisited hypothesis in a sheep model |
title_fullStr |
Postnatal pituitary and follicular activation A revisited hypothesis in a sheep model |
title_full_unstemmed |
Postnatal pituitary and follicular activation A revisited hypothesis in a sheep model |
title_sort |
postnatal pituitary and follicular activation a revisited hypothesis in a sheep model |
publishDate |
2016 |
url |
http://hdl.handle.net/20.500.12792/4551 |
work_keys_str_mv |
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