Environmental risk assessment of ivermectin A case study

The veterinary parasiticide ivermectin was selected as a case study compound within the project ERAPharm (Environmental Risk Assessment of Pharmaceuticals). Based on experimental data generated within ERAPharm and additional literature data, an environmental risk assessment (ERA) was performed mainly according to international and European guidelines. For the environmental compartments surface water, sediment, and dung, a risk was indicated at all levels of the tiered assessment approach. Only for soil was no risk indicated after the lower tier assessment. However, the use of effects data from additional 2-species and multispecies studies resulted in a risk indication for collembolans. Although previously performed ERAs for ivermectin revealed no concern for the aquatic compartment, and transient effects on dung-insect populations were not considered as relevant, the present ERA clearly demonstrates unacceptable risks for all investigated environmental compartments and hence suggests the necessity of reassessing ivermectin-containing products. Based on this case study, several gaps in the existing guidelines for ERA of pharmaceuticals were shown and improvements have been suggested. The action limit at the start of the ERA, for example, is not protective for substances such as ivermectin when used on intensively reared animals. Furthermore, initial predicted environmental concentrations (PECs) of ivermectin in soil were estimated to be lower than refined PECs, indicating that the currently used tiered approach for exposure assessment is not appropriate for substances with potential for accumulation in soil. In addition, guidance is lacking for the assessment of effects at higher tiers of the ERA, e.g.;for field studies or a tiered effects assessment in the dung compartment. Integr Environ Assess Manag 2010;6567587. © 2010 SETAC.

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Main Authors: Liebig, M., Fernandez, A. A., Blübaum-Gronau, E., Boxall, A., Brinke, M., Carbonell, G., Egeler, H., Fenner, K., Fernandez, C., Fink, G., Garric, J., Halling-Sørensen, B., Knacker, T., Krogh, K. A., Küster, A., Dirk, Löffler, Cots, M. A. P., Pope, L., Prasse, C., Römbke, J., Rönnefahrt, I., Schneider, M. K., Schweitzer, N., Tarazona, J. V., Ternes, T. A., Traunspurger, W., Wehrhan, A., Duisy, K.
Format: journal article biblioteca
Language:English
Published: Wiley 2010
Subjects:Environmental risk assessment, Fate and effects assessment, Parasiticides, Tiered approach, Veterinary pharmaceuticals,
Online Access:http://hdl.handle.net/20.500.12792/2391
http://hdl.handle.net/10261/293811
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spelling dig-inia-es-10261-2938112023-02-20T10:32:19Z Environmental risk assessment of ivermectin A case study Liebig, M. Fernandez, A. A. Blübaum-Gronau, E. Boxall, A. Brinke, M. Carbonell, G. Egeler, H. Fenner, K. Fernandez, C. Fink, G. Garric, J. Halling-Sørensen, B. Knacker, T. Krogh, K. A. Küster, A. Dirk, Löffler, Cots, M. A. P. Pope, L. Prasse, C. Römbke, J. Rönnefahrt, I. Schneider, M. K. Schweitzer, N. Tarazona, J. V. Ternes, T. A. Traunspurger, W. Wehrhan, A. Duisy, K. Environmental risk assessment Fate and effects assessment Parasiticides Tiered approach Veterinary pharmaceuticals The veterinary parasiticide ivermectin was selected as a case study compound within the project ERAPharm (Environmental Risk Assessment of Pharmaceuticals). Based on experimental data generated within ERAPharm and additional literature data, an environmental risk assessment (ERA) was performed mainly according to international and European guidelines. For the environmental compartments surface water, sediment, and dung, a risk was indicated at all levels of the tiered assessment approach. Only for soil was no risk indicated after the lower tier assessment. However, the use of effects data from additional 2-species and multispecies studies resulted in a risk indication for collembolans. Although previously performed ERAs for ivermectin revealed no concern for the aquatic compartment, and transient effects on dung-insect populations were not considered as relevant, the present ERA clearly demonstrates unacceptable risks for all investigated environmental compartments and hence suggests the necessity of reassessing ivermectin-containing products. Based on this case study, several gaps in the existing guidelines for ERA of pharmaceuticals were shown and improvements have been suggested. The action limit at the start of the ERA, for example, is not protective for substances such as ivermectin when used on intensively reared animals. Furthermore, initial predicted environmental concentrations (PECs) of ivermectin in soil were estimated to be lower than refined PECs, indicating that the currently used tiered approach for exposure assessment is not appropriate for substances with potential for accumulation in soil. In addition, guidance is lacking for the assessment of effects at higher tiers of the ERA, e.g.;for field studies or a tiered effects assessment in the dung compartment. Integr Environ Assess Manag 2010;6567587. © 2010 SETAC. 2023-02-20T10:32:19Z 2023-02-20T10:32:19Z 2010 journal article Integrated Environmental Assessment and Management 6(1): 567-587 (2010) 1551-3777 http://hdl.handle.net/20.500.12792/2391 http://hdl.handle.net/10261/293811 10.1002/ieam.96 1551-3793 en none Wiley
institution INIA ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-inia-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del INIA España
language English
topic Environmental risk assessment
Fate and effects assessment
Parasiticides
Tiered approach
Veterinary pharmaceuticals
Environmental risk assessment
Fate and effects assessment
Parasiticides
Tiered approach
Veterinary pharmaceuticals
spellingShingle Environmental risk assessment
Fate and effects assessment
Parasiticides
Tiered approach
Veterinary pharmaceuticals
Environmental risk assessment
Fate and effects assessment
Parasiticides
Tiered approach
Veterinary pharmaceuticals
Liebig, M.
Fernandez, A. A.
Blübaum-Gronau, E.
Boxall, A.
Brinke, M.
Carbonell, G.
Egeler, H.
Fenner, K.
Fernandez, C.
Fink, G.
Garric, J.
Halling-Sørensen, B.
Knacker, T.
Krogh, K. A.
Küster, A.
Dirk, Löffler, Cots, M. A. P.
Pope, L.
Prasse, C.
Römbke, J.
Rönnefahrt, I.
Schneider, M. K.
Schweitzer, N.
Tarazona, J. V.
Ternes, T. A.
Traunspurger, W.
Wehrhan, A.
Duisy, K.
Environmental risk assessment of ivermectin A case study
description The veterinary parasiticide ivermectin was selected as a case study compound within the project ERAPharm (Environmental Risk Assessment of Pharmaceuticals). Based on experimental data generated within ERAPharm and additional literature data, an environmental risk assessment (ERA) was performed mainly according to international and European guidelines. For the environmental compartments surface water, sediment, and dung, a risk was indicated at all levels of the tiered assessment approach. Only for soil was no risk indicated after the lower tier assessment. However, the use of effects data from additional 2-species and multispecies studies resulted in a risk indication for collembolans. Although previously performed ERAs for ivermectin revealed no concern for the aquatic compartment, and transient effects on dung-insect populations were not considered as relevant, the present ERA clearly demonstrates unacceptable risks for all investigated environmental compartments and hence suggests the necessity of reassessing ivermectin-containing products. Based on this case study, several gaps in the existing guidelines for ERA of pharmaceuticals were shown and improvements have been suggested. The action limit at the start of the ERA, for example, is not protective for substances such as ivermectin when used on intensively reared animals. Furthermore, initial predicted environmental concentrations (PECs) of ivermectin in soil were estimated to be lower than refined PECs, indicating that the currently used tiered approach for exposure assessment is not appropriate for substances with potential for accumulation in soil. In addition, guidance is lacking for the assessment of effects at higher tiers of the ERA, e.g.;for field studies or a tiered effects assessment in the dung compartment. Integr Environ Assess Manag 2010;6567587. © 2010 SETAC.
format journal article
topic_facet Environmental risk assessment
Fate and effects assessment
Parasiticides
Tiered approach
Veterinary pharmaceuticals
author Liebig, M.
Fernandez, A. A.
Blübaum-Gronau, E.
Boxall, A.
Brinke, M.
Carbonell, G.
Egeler, H.
Fenner, K.
Fernandez, C.
Fink, G.
Garric, J.
Halling-Sørensen, B.
Knacker, T.
Krogh, K. A.
Küster, A.
Dirk, Löffler, Cots, M. A. P.
Pope, L.
Prasse, C.
Römbke, J.
Rönnefahrt, I.
Schneider, M. K.
Schweitzer, N.
Tarazona, J. V.
Ternes, T. A.
Traunspurger, W.
Wehrhan, A.
Duisy, K.
author_facet Liebig, M.
Fernandez, A. A.
Blübaum-Gronau, E.
Boxall, A.
Brinke, M.
Carbonell, G.
Egeler, H.
Fenner, K.
Fernandez, C.
Fink, G.
Garric, J.
Halling-Sørensen, B.
Knacker, T.
Krogh, K. A.
Küster, A.
Dirk, Löffler, Cots, M. A. P.
Pope, L.
Prasse, C.
Römbke, J.
Rönnefahrt, I.
Schneider, M. K.
Schweitzer, N.
Tarazona, J. V.
Ternes, T. A.
Traunspurger, W.
Wehrhan, A.
Duisy, K.
author_sort Liebig, M.
title Environmental risk assessment of ivermectin A case study
title_short Environmental risk assessment of ivermectin A case study
title_full Environmental risk assessment of ivermectin A case study
title_fullStr Environmental risk assessment of ivermectin A case study
title_full_unstemmed Environmental risk assessment of ivermectin A case study
title_sort environmental risk assessment of ivermectin a case study
publisher Wiley
publishDate 2010
url http://hdl.handle.net/20.500.12792/2391
http://hdl.handle.net/10261/293811
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