Characterization of the porcine FABP5 gene and its association with the FAT1 QTL in an Iberian by Landrace cross
We have characterized and mapped the porcine fatty acid binding protein 5, epidermal (FABP5) gene. According to linkage and RH mapping, this gene is located close to the FABP4 (fatty acid binding protein 4, adipocyte) gene on swine chromosome 4. We resequenced 4.7 kb of the FABP5 gene in the parental population of an Iberian x Landrace cross (IBMAP), identifying seven SNPs arranged in two distinct FABP5 haplotypes. QTL and association analyses in the IBMAP population showed that this gene is strongly associated with fat deposition. QTL and haplotype analysis revealed that both FABP4 and FABP5 (clustered in mammals) are major candidate genes for the FAT1 QTL; the most likely position for the FAT1 QTL is between these two genes. Finally, our results suggest the presence of more than one QTL affecting fatness traits on porcine chromosome 4. © 2006 The Authors.
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Format: | artículo biblioteca |
Language: | English |
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Wiley
2006
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Subjects: | Fatness, Fatty acid binding protein, Pig, QTL, |
Online Access: | http://hdl.handle.net/20.500.12792/5052 http://hdl.handle.net/10261/290067 |
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dig-inia-es-10261-2900672023-02-17T08:27:03Z Characterization of the porcine FABP5 gene and its association with the FAT1 QTL in an Iberian by Landrace cross Estellé, J. Pérez-Enciso, M. Mercadé, A. Varona, L. Alves, E. Sánchez, A. Folch, J. M. Fatness Fatty acid binding protein Pig QTL We have characterized and mapped the porcine fatty acid binding protein 5, epidermal (FABP5) gene. According to linkage and RH mapping, this gene is located close to the FABP4 (fatty acid binding protein 4, adipocyte) gene on swine chromosome 4. We resequenced 4.7 kb of the FABP5 gene in the parental population of an Iberian x Landrace cross (IBMAP), identifying seven SNPs arranged in two distinct FABP5 haplotypes. QTL and association analyses in the IBMAP population showed that this gene is strongly associated with fat deposition. QTL and haplotype analysis revealed that both FABP4 and FABP5 (clustered in mammals) are major candidate genes for the FAT1 QTL; the most likely position for the FAT1 QTL is between these two genes. Finally, our results suggest the presence of more than one QTL affecting fatness traits on porcine chromosome 4. © 2006 The Authors. 2023-02-17T08:27:03Z 2023-02-17T08:27:03Z 2006 artículo Animal Genetics 37(6): 589-591 (2007) 0268-9146 http://hdl.handle.net/20.500.12792/5052 http://hdl.handle.net/10261/290067 10.1111/j.1365-2052.2006.01535.x 1365-2052 en none Wiley |
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Fatness Fatty acid binding protein Pig QTL Fatness Fatty acid binding protein Pig QTL |
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Fatness Fatty acid binding protein Pig QTL Fatness Fatty acid binding protein Pig QTL Estellé, J. Pérez-Enciso, M. Mercadé, A. Varona, L. Alves, E. Sánchez, A. Folch, J. M. Characterization of the porcine FABP5 gene and its association with the FAT1 QTL in an Iberian by Landrace cross |
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We have characterized and mapped the porcine fatty acid binding protein 5, epidermal (FABP5) gene. According to linkage and RH mapping, this gene is located close to the FABP4 (fatty acid binding protein 4, adipocyte) gene on swine chromosome 4. We resequenced 4.7 kb of the FABP5 gene in the parental population of an Iberian x Landrace cross (IBMAP), identifying seven SNPs arranged in two distinct FABP5 haplotypes. QTL and association analyses in the IBMAP population showed that this gene is strongly associated with fat deposition. QTL and haplotype analysis revealed that both FABP4 and FABP5 (clustered in mammals) are major candidate genes for the FAT1 QTL; the most likely position for the FAT1 QTL is between these two genes. Finally, our results suggest the presence of more than one QTL affecting fatness traits on porcine chromosome 4. © 2006 The Authors. |
format |
artículo |
topic_facet |
Fatness Fatty acid binding protein Pig QTL |
author |
Estellé, J. Pérez-Enciso, M. Mercadé, A. Varona, L. Alves, E. Sánchez, A. Folch, J. M. |
author_facet |
Estellé, J. Pérez-Enciso, M. Mercadé, A. Varona, L. Alves, E. Sánchez, A. Folch, J. M. |
author_sort |
Estellé, J. |
title |
Characterization of the porcine FABP5 gene and its association with the FAT1 QTL in an Iberian by Landrace cross |
title_short |
Characterization of the porcine FABP5 gene and its association with the FAT1 QTL in an Iberian by Landrace cross |
title_full |
Characterization of the porcine FABP5 gene and its association with the FAT1 QTL in an Iberian by Landrace cross |
title_fullStr |
Characterization of the porcine FABP5 gene and its association with the FAT1 QTL in an Iberian by Landrace cross |
title_full_unstemmed |
Characterization of the porcine FABP5 gene and its association with the FAT1 QTL in an Iberian by Landrace cross |
title_sort |
characterization of the porcine fabp5 gene and its association with the fat1 qtl in an iberian by landrace cross |
publisher |
Wiley |
publishDate |
2006 |
url |
http://hdl.handle.net/20.500.12792/5052 http://hdl.handle.net/10261/290067 |
work_keys_str_mv |
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