Viral Vector Vaccines against Bluetongue Virus
19 Pág. Centro de Investigación en Sanidad Animal (CISA)
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| Language: | English |
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Multidisciplinary Digital Publishing Institute
2020-12-25
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| Subjects: | Bluetongue virus (BTV), Humoral and cellular immune responses, Multiserotype protection, Recombinant vaccines, Viral vectors, |
| Online Access: | http://hdl.handle.net/10261/287543 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100000780 https://api.elsevier.com/content/abstract/scopus_id/85098885495 |
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dig-inia-es-10261-2875432023-02-01T21:36:07Z Viral Vector Vaccines against Bluetongue Virus Jiménez-Cabello, Luis Utrilla-Trigo, Sergio Calvo-Pinilla, Eva Moreno, Sandra Nogales, Aitor Ortego, Javier Marín-López, Alejandro Ministerio de Ciencia e Innovación (España) European Commission Centro de Investigación en Sanidad Animal (España) Ministerio de Economía y Competitividad (España) Jiménez-Cabello, Luis [0000-0001-8085-5823] Utrilla-Trigo, Sergio [0000-0002-7672-7658] Calvo-Pinilla, Eva [0000-0002-4667-4081] Nogales, Aitor [0000-0002-2424-7900] Ortego, Javier [0000-0002-4275-7277] Marín-López, Alejandro [0000-0003-2840-1722] Bluetongue virus (BTV) Humoral and cellular immune responses Multiserotype protection Recombinant vaccines Viral vectors 19 Pág. Centro de Investigación en Sanidad Animal (CISA) 9, Issue 1, Pages 1 - 21January 2021 Bluetongue virus (BTV), the prototype member of the genus Orbivirus (family Reoviridae), is the causative agent of an important livestock disease, bluetongue (BT), which is transmitted via biting midges of the genus Culicoides. To date, up to 29 serotypes of BTV have been described, which are classified as classical (BTV 1-24) or atypical (serotypes 25-27), and its distribution has been expanding since 1998, with important outbreaks in the Mediterranean Basin and devastating incursions in Northern and Western Europe. Classical vaccine approaches, such as live-attenuated and inactivated vaccines, have been used as prophylactic measures to control BT through the years. However, these vaccine approaches fail to address important matters like vaccine safety profile, effectiveness, induction of a cross-protective immune response among serotypes, and implementation of a DIVA (differentiation of infected from vaccinated animals) strategy. In this context, a wide range of recombinant vaccine prototypes against BTV, ranging from subunit vaccines to recombinant viral vector vaccines, have been investigated. This article offers a comprehensive outline of the live viral vectors used against BTV. This work was supported by grants AGL2017-82570-R from the Spanish Ministry of Science and the EU Horizon 2020 Program (European Commission Grant Agreement No. 727393-PALE-Blu). S.U.-T. was a recipient of a predoctoral fellowship from the Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Centro de Investigación en Sanidad Animal (program FPI-SGIT 201). A.N. is supported by a MINECO “Ramon y Cajal” Incorporación grant (RYC-2017). Peer reviewed 2023-01-25T13:20:43Z 2023-01-25T13:20:43Z 2020-12-25 artículo Microorganisms 9(1): 1-21 (2021) 2076-2607 http://hdl.handle.net/10261/287543 10.3390/microorganisms9010042 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100000780 33375723 2-s2.0-85098885495 https://api.elsevier.com/content/abstract/scopus_id/85098885495 en #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2017-82570-R/ES/DESARROLLO DE VACUNAS DIVA UNIVERSALES FRENTE AL VIRUS DE LA LENGUA AZUL BASADAS EN RESPUESTA INMUNE CELULAR INDUCIDA POR LAS PROTEINAS NO ESTRUCTURALES DEL VIRUS CONSERVADAS/ info:eu-repo/grantAgreement/EC/H2020/727393 info:eu-repo/grantAgreement/CISA//FPI-SGIT 201 info:eu-repo/grantAgreement/MINECO//RYC-2017 Microorganisms Publisher's version https://doi.org/10.3390/microorganisms9010042 Sí open Multidisciplinary Digital Publishing Institute |
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Bluetongue virus (BTV) Humoral and cellular immune responses Multiserotype protection Recombinant vaccines Viral vectors Bluetongue virus (BTV) Humoral and cellular immune responses Multiserotype protection Recombinant vaccines Viral vectors |
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Bluetongue virus (BTV) Humoral and cellular immune responses Multiserotype protection Recombinant vaccines Viral vectors Bluetongue virus (BTV) Humoral and cellular immune responses Multiserotype protection Recombinant vaccines Viral vectors Jiménez-Cabello, Luis Utrilla-Trigo, Sergio Calvo-Pinilla, Eva Moreno, Sandra Nogales, Aitor Ortego, Javier Marín-López, Alejandro Viral Vector Vaccines against Bluetongue Virus |
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19 Pág.
Centro de Investigación en Sanidad Animal (CISA) |
| author2 |
Ministerio de Ciencia e Innovación (España) |
| author_facet |
Ministerio de Ciencia e Innovación (España) Jiménez-Cabello, Luis Utrilla-Trigo, Sergio Calvo-Pinilla, Eva Moreno, Sandra Nogales, Aitor Ortego, Javier Marín-López, Alejandro |
| format |
artículo |
| topic_facet |
Bluetongue virus (BTV) Humoral and cellular immune responses Multiserotype protection Recombinant vaccines Viral vectors |
| author |
Jiménez-Cabello, Luis Utrilla-Trigo, Sergio Calvo-Pinilla, Eva Moreno, Sandra Nogales, Aitor Ortego, Javier Marín-López, Alejandro |
| author_sort |
Jiménez-Cabello, Luis |
| title |
Viral Vector Vaccines against Bluetongue Virus |
| title_short |
Viral Vector Vaccines against Bluetongue Virus |
| title_full |
Viral Vector Vaccines against Bluetongue Virus |
| title_fullStr |
Viral Vector Vaccines against Bluetongue Virus |
| title_full_unstemmed |
Viral Vector Vaccines against Bluetongue Virus |
| title_sort |
viral vector vaccines against bluetongue virus |
| publisher |
Multidisciplinary Digital Publishing Institute |
| publishDate |
2020-12-25 |
| url |
http://hdl.handle.net/10261/287543 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100000780 https://api.elsevier.com/content/abstract/scopus_id/85098885495 |
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