The role of feed restriction on DNA methylation, feed efficiency, metabolome, biochemical profile, and progesterone patterns in the female filial generation (f1) obtained from early feed restricted ewes (F0)

Andrés, Sonia; Madsen, O.; Montero, Olimpio; Martín, Alba; Giráldez, Francisco Javier; Ministerio de Ciencia e Innovación (España)

The role of feed restriction on DNA methylation, feed efficiency, metabolome, biochemical profile, and progesterone patterns in the female filial generation (f1) obtained from early feed restricted ewes (F0)

12 páginas, 1 figura, 4 tablas.

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Bibliographic Details
Main Authors:	Andrés, Sonia, Madsen, O., Montero, Olimpio, Martín, Alba, Giráldez, Francisco Javier
Other Authors:	Ministerio de Ciencia e Innovación (España)
Format:	artículo biblioteca
Language:	English
Published:	Frontiers Media 2021
Subjects:	Feed efficiency, Nutritional programming, Feed restriction, Progesterone, Cholic acid, Metabolomics, Epigenetics,
Online Access:	http://hdl.handle.net/10261/258154 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100000780
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spelling	dig-igm-es-10261-2581542022-02-15T12:39:14Z The role of feed restriction on DNA methylation, feed efficiency, metabolome, biochemical profile, and progesterone patterns in the female filial generation (f1) obtained from early feed restricted ewes (F0) Andrés, Sonia Madsen, O. Montero, Olimpio Martín, Alba Giráldez, Francisco Javier Ministerio de Ciencia e Innovación (España) European Commission Andrés, Sonia [0000-0001-5255-1582] Giráldez, Francisco Javier [0000-0002-0680-1541] Feed efficiency Nutritional programming Feed restriction Progesterone Cholic acid Metabolomics Epigenetics 12 páginas, 1 figura, 4 tablas. Deficient management of replacement animals in the farm during early developmental windows may promote adverse programming effects on reproductive traits and subsequent transmission to the next generation. In this sense, DNA methylation profiles allow researchers to decode epigenetic regulation mechanisms in mammals and identify novel candidate genes correlated with phenotype differences in both dams and offspring. Therefore, improving knowledge in the field of epigenetics and intergenerational effects caused by prenatal and postnatal early nutritional events (e.g., feed restriction) is crucial for refining strategies dedicated to animal breeding. In this study, we determined differences in the global blood methylation patterns, biochemical profile, and metabolome of ewe lambs (F1) born from either early feed restricted dams (F0-RES) or fed ad libitum (F0-ADL). Our data show that functional categories such as those related to cellular processes, phosphorylation, nervous system, immunity response, or reproductive function were enriched significantly in the F1-RES lambs due to differences in the methylation of genes in these categories. These F1-RES lambs did not show differences in feed efficiency during the replacement period but presented higher levels of insulin and triglycerides and reduced concentration of progesterone, whereas the metabolome profile demonstrated variations in the bile acid composition when compared with the F1-ADL lambs. Taken together, all these results suggest that intergenerational effects caused by early feed restriction of dams (F0) may persist in the F1 female lambs with negative consequences on genes involved in cellular processes and reproductive traits. This study was funded by Ministerio de Ciencia e Innovación (RTI2018-099329-B-I00, MCIN/AEI/10.13039/501100011033, FEDER, Una manera de hacer Europa). AM gratefully acknowledges the receipt of a predoctoral grant (PRE2019- 089288) from Ministerio de Ciencia e Innovación (MCIN/AEI/10.13039/501100011033, El FSE invierte en tu futuro). Peer reviewed 2022-01-19T10:29:28Z 2022-01-19T10:29:28Z 2021 artículo http://purl.org/coar/resource_type/c_6501 Frontiers in physiology, 12: 779054 (2021) http://hdl.handle.net/10261/258154 10.3389/fphys.2021.779054 1664-042X http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100000780 en #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación (PEICTI) 2017-2020/RTI2018-099329-B-I00 info:eu-repo/grantAgreement/AEI//PRE2019-089288 Publisher's version http://dx.doi.org/10.3389/fphys.2021.779054 Sí open Frontiers Media
institution	IGM ES
collection	DSpace
country	España
countrycode	ES
component	Bibliográfico
access	En linea
databasecode	dig-igm-es
tag	biblioteca
region	Europa del Sur
libraryname	Biblioteca del IGM España
language	English
topic	Feed efficiency Nutritional programming Feed restriction Progesterone Cholic acid Metabolomics Epigenetics Feed efficiency Nutritional programming Feed restriction Progesterone Cholic acid Metabolomics Epigenetics
spellingShingle	Feed efficiency Nutritional programming Feed restriction Progesterone Cholic acid Metabolomics Epigenetics Feed efficiency Nutritional programming Feed restriction Progesterone Cholic acid Metabolomics Epigenetics Andrés, Sonia Madsen, O. Montero, Olimpio Martín, Alba Giráldez, Francisco Javier The role of feed restriction on DNA methylation, feed efficiency, metabolome, biochemical profile, and progesterone patterns in the female filial generation (f1) obtained from early feed restricted ewes (F0)
description	12 páginas, 1 figura, 4 tablas.
author2	Ministerio de Ciencia e Innovación (España)
author_facet	Ministerio de Ciencia e Innovación (España) Andrés, Sonia Madsen, O. Montero, Olimpio Martín, Alba Giráldez, Francisco Javier
format	artículo
topic_facet	Feed efficiency Nutritional programming Feed restriction Progesterone Cholic acid Metabolomics Epigenetics
author	Andrés, Sonia Madsen, O. Montero, Olimpio Martín, Alba Giráldez, Francisco Javier
author_sort	Andrés, Sonia
title	The role of feed restriction on DNA methylation, feed efficiency, metabolome, biochemical profile, and progesterone patterns in the female filial generation (f1) obtained from early feed restricted ewes (F0)
title_short	The role of feed restriction on DNA methylation, feed efficiency, metabolome, biochemical profile, and progesterone patterns in the female filial generation (f1) obtained from early feed restricted ewes (F0)
title_full	The role of feed restriction on DNA methylation, feed efficiency, metabolome, biochemical profile, and progesterone patterns in the female filial generation (f1) obtained from early feed restricted ewes (F0)
title_fullStr	The role of feed restriction on DNA methylation, feed efficiency, metabolome, biochemical profile, and progesterone patterns in the female filial generation (f1) obtained from early feed restricted ewes (F0)
title_full_unstemmed	The role of feed restriction on DNA methylation, feed efficiency, metabolome, biochemical profile, and progesterone patterns in the female filial generation (f1) obtained from early feed restricted ewes (F0)
title_sort	role of feed restriction on dna methylation, feed efficiency, metabolome, biochemical profile, and progesterone patterns in the female filial generation (f1) obtained from early feed restricted ewes (f0)
publisher	Frontiers Media
publishDate	2021
url	http://hdl.handle.net/10261/258154 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100000780
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The role of feed restriction on DNA methylation, feed efficiency, metabolome, biochemical profile, and progesterone patterns in the female filial generation (f1) obtained from early feed restricted ewes (F0)

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