Accumulation of perfluoroalkyl substances in human tissues
Perfluoroalkyl substances (PFASs) are environmental pollutants with an important bioaccumulation potential. However, their metabolism and distribution in humans are not well studied. In this study, the concentrations of 21 PFASs were analyzed in 99 samples of autopsy tissues (brain, liver, lung, bone, and kidney) from subjects who had been living in Tarragona (Catalonia, Spain). The samples were analyzed by solvent extraction and online purification by turbulent flow and liquid chromatography coupled to tandem mass spectrometry. The occurrence of PFASs was confirmed in all human tissues. Although PFASs accumulation followed particular trends depending on the specific tissue, some similarities were found. In kidney and lung, perfluorobutanoic acid was the most frequent compound, and at highest concentrations (median values: 263 and 807. ng/g in kidney and lung, respectively). In liver and brain, perfluorohexanoic acid showed the maximum levels (median: 68.3 and 141. ng/g, respectively), while perfluorooctanoic acid was the most contributively in bone (median: 20.9. ng/g). Lung tissues accumulated the highest concentration of PFASs. However, perfluorooctane sulfonic acid and perfluorooctanoic acid were more prevalent in liver and bone, respectively. To the best of our knowledge, the accumulation of different PFASs in samples of various human tissues from the same subjects is here reported for the very first time. The current results may be of high importance for the validation of physiologically based pharmacokinetic models, which are being developed for humans. However, further studies on the distribution of the same compounds in the human body are still required. © 2013 Elsevier Ltd.
Auteurs principaux: | Pérez, Francisca, Nadal, M., Navarro-Ortega, Alícia, Fàbrega, Francesc, Domingo, J.L., Barceló, Damià, Farré, Marinella |
---|---|
Autres auteurs: | Ministerio de Ciencia, Innovación y Universidades (España) |
Format: | artículo biblioteca |
Publié: |
Pergamon Press
2013
|
Accès en ligne: | http://hdl.handle.net/10261/217846 http://dx.doi.org/10.13039/501100002383 http://dx.doi.org/10.13039/501100002809 |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
Adsorption of perfluoroalkyl substances on microplastics under environmental conditions
par: Llorca, Marta, et autres
Publié: (2018-04) -
Perfluoroalkyl substances assessment in drinking waters from Brazil, France and Spain
par: Schwanz, Thiago G., et autres
Publié: (2016-01-01) -
Delivery of unprecedented amounts of perfluoroalkyl substances towards the deep-sea
par: Sánchez-Vidal, Anna, et autres -
Delivery of unprecedented amounts of perfluoroalkyl substances towards the deep-sea
par: Sánchez-Vidal, Anna, et autres -
Assessment of perfluoroalkyl substances in food items at global scale
par: Pérez, Francisca, et autres
Publié: (2014-11)