Accumulation of perfluoroalkyl substances in human tissues
Perfluoroalkyl substances (PFASs) are environmental pollutants with an important bioaccumulation potential. However, their metabolism and distribution in humans are not well studied. In this study, the concentrations of 21 PFASs were analyzed in 99 samples of autopsy tissues (brain, liver, lung, bone, and kidney) from subjects who had been living in Tarragona (Catalonia, Spain). The samples were analyzed by solvent extraction and online purification by turbulent flow and liquid chromatography coupled to tandem mass spectrometry. The occurrence of PFASs was confirmed in all human tissues. Although PFASs accumulation followed particular trends depending on the specific tissue, some similarities were found. In kidney and lung, perfluorobutanoic acid was the most frequent compound, and at highest concentrations (median values: 263 and 807. ng/g in kidney and lung, respectively). In liver and brain, perfluorohexanoic acid showed the maximum levels (median: 68.3 and 141. ng/g, respectively), while perfluorooctanoic acid was the most contributively in bone (median: 20.9. ng/g). Lung tissues accumulated the highest concentration of PFASs. However, perfluorooctane sulfonic acid and perfluorooctanoic acid were more prevalent in liver and bone, respectively. To the best of our knowledge, the accumulation of different PFASs in samples of various human tissues from the same subjects is here reported for the very first time. The current results may be of high importance for the validation of physiologically based pharmacokinetic models, which are being developed for humans. However, further studies on the distribution of the same compounds in the human body are still required. © 2013 Elsevier Ltd.
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2013
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dig-idaea-es-10261-2178462022-05-27T09:02:38Z Accumulation of perfluoroalkyl substances in human tissues Pérez, Francisca Nadal, M. Navarro-Ortega, Alícia Fàbrega, Francesc Domingo, J.L. Barceló, Damià Farré, Marinella Ministerio de Ciencia, Innovación y Universidades (España) King Saud University Generalitat de Catalunya Perfluoroalkyl substances (PFASs) are environmental pollutants with an important bioaccumulation potential. However, their metabolism and distribution in humans are not well studied. In this study, the concentrations of 21 PFASs were analyzed in 99 samples of autopsy tissues (brain, liver, lung, bone, and kidney) from subjects who had been living in Tarragona (Catalonia, Spain). The samples were analyzed by solvent extraction and online purification by turbulent flow and liquid chromatography coupled to tandem mass spectrometry. The occurrence of PFASs was confirmed in all human tissues. Although PFASs accumulation followed particular trends depending on the specific tissue, some similarities were found. In kidney and lung, perfluorobutanoic acid was the most frequent compound, and at highest concentrations (median values: 263 and 807. ng/g in kidney and lung, respectively). In liver and brain, perfluorohexanoic acid showed the maximum levels (median: 68.3 and 141. ng/g, respectively), while perfluorooctanoic acid was the most contributively in bone (median: 20.9. ng/g). Lung tissues accumulated the highest concentration of PFASs. However, perfluorooctane sulfonic acid and perfluorooctanoic acid were more prevalent in liver and bone, respectively. To the best of our knowledge, the accumulation of different PFASs in samples of various human tissues from the same subjects is here reported for the very first time. The current results may be of high importance for the validation of physiologically based pharmacokinetic models, which are being developed for humans. However, further studies on the distribution of the same compounds in the human body are still required. © 2013 Elsevier Ltd. This work was supported by the Spanish Ministry of Science and Innovation, through the project SCARCE Consolider Ingenio 2010 CSD2009-00065 and by King Saud University grant number (KSU-VPP-105). This work was partly supported by the Generalitat de Catalunya (Consolidated Research Groups: Water and Soil Quality Unit 2009-SGR-965 and Laboratory of Toxicology and Environmental Health 2009-SGR-1133). Thermo Company is acknowledged for providing free columns. 2020-08-12T10:55:03Z 2020-08-12T10:55:03Z 2013 2020-08-12T10:55:04Z artículo http://purl.org/coar/resource_type/c_6501 doi: 10.1016/j.envint.2013.06.004 issn: 0160-4120 Environmental International 59: 354- 362 (2013) http://hdl.handle.net/10261/217846 10.1016/j.envint.2013.06.004 http://dx.doi.org/10.13039/501100002383 http://dx.doi.org/10.13039/501100002809 Publisher's version http://dx.doi.org/10.1016/j.envint.2013.06.004 Sí open Pergamon Press |
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Perfluoroalkyl substances (PFASs) are environmental pollutants with an important bioaccumulation potential. However, their metabolism and distribution in humans are not well studied. In this study, the concentrations of 21 PFASs were analyzed in 99 samples of autopsy tissues (brain, liver, lung, bone, and kidney) from subjects who had been living in Tarragona (Catalonia, Spain). The samples were analyzed by solvent extraction and online purification by turbulent flow and liquid chromatography coupled to tandem mass spectrometry. The occurrence of PFASs was confirmed in all human tissues. Although PFASs accumulation followed particular trends depending on the specific tissue, some similarities were found. In kidney and lung, perfluorobutanoic acid was the most frequent compound, and at highest concentrations (median values: 263 and 807. ng/g in kidney and lung, respectively). In liver and brain, perfluorohexanoic acid showed the maximum levels (median: 68.3 and 141. ng/g, respectively), while perfluorooctanoic acid was the most contributively in bone (median: 20.9. ng/g). Lung tissues accumulated the highest concentration of PFASs. However, perfluorooctane sulfonic acid and perfluorooctanoic acid were more prevalent in liver and bone, respectively. To the best of our knowledge, the accumulation of different PFASs in samples of various human tissues from the same subjects is here reported for the very first time. The current results may be of high importance for the validation of physiologically based pharmacokinetic models, which are being developed for humans. However, further studies on the distribution of the same compounds in the human body are still required. © 2013 Elsevier Ltd. |
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Ministerio de Ciencia, Innovación y Universidades (España) |
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Ministerio de Ciencia, Innovación y Universidades (España) Pérez, Francisca Nadal, M. Navarro-Ortega, Alícia Fàbrega, Francesc Domingo, J.L. Barceló, Damià Farré, Marinella |
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artículo |
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Pérez, Francisca Nadal, M. Navarro-Ortega, Alícia Fàbrega, Francesc Domingo, J.L. Barceló, Damià Farré, Marinella |
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Pérez, Francisca Nadal, M. Navarro-Ortega, Alícia Fàbrega, Francesc Domingo, J.L. Barceló, Damià Farré, Marinella Accumulation of perfluoroalkyl substances in human tissues |
author_sort |
Pérez, Francisca |
title |
Accumulation of perfluoroalkyl substances in human tissues |
title_short |
Accumulation of perfluoroalkyl substances in human tissues |
title_full |
Accumulation of perfluoroalkyl substances in human tissues |
title_fullStr |
Accumulation of perfluoroalkyl substances in human tissues |
title_full_unstemmed |
Accumulation of perfluoroalkyl substances in human tissues |
title_sort |
accumulation of perfluoroalkyl substances in human tissues |
publisher |
Pergamon Press |
publishDate |
2013 |
url |
http://hdl.handle.net/10261/217846 http://dx.doi.org/10.13039/501100002383 http://dx.doi.org/10.13039/501100002809 |
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