Preventive effects of cocoa and cocoa antioxidants in colon cancer
Colorectal cancer is one of the main causes of cancer-related mortality in the developed world. Carcinogenesis is a multistage process conventionally defined by the initiation, promotion and progression stages. Natural polyphenolic compounds can act as highly effective antioxidant and chemo-preventive agents able to interfere at the three stages of cancer. Cocoa has been demonstrated to counteract oxidative stress and to have a potential capacity to interact with multiple carcinogenic pathways involved in inflammation, proliferation and apoptosis of initiated and malignant cells. Therefore, restriction of oxidative stress and/or prevention or delayed progression of cancer stages by cocoa antioxidant compounds has gained interest as an effective approach in colorectal cancer prevention. In this review, we look over different in vitro and in vivo studies that have identified potential targets and mechanisms whereby cocoa and their flavonoids could interfere with colonic cancer. In addition, evidence from human studies is also illustrated.
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Format: | artículo biblioteca |
Language: | English |
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Multidisciplinary Digital Publishing Institute
2016-01-21
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Subjects: | Cocoa flavonoids, Colon cancer, In vitro and in vivo studies, Molecular mechanism, |
Online Access: | http://hdl.handle.net/10261/135866 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100003339 |
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dig-ictan-es-10261-1358662022-01-26T09:13:44Z Preventive effects of cocoa and cocoa antioxidants in colon cancer Martín, M. Ángeles Goya, Luis Ramos, Sonia Ministerio de Ciencia e Innovación (España) Consejo Superior de Investigaciones Científicas (España) Cocoa flavonoids Colon cancer In vitro and in vivo studies Molecular mechanism Colorectal cancer is one of the main causes of cancer-related mortality in the developed world. Carcinogenesis is a multistage process conventionally defined by the initiation, promotion and progression stages. Natural polyphenolic compounds can act as highly effective antioxidant and chemo-preventive agents able to interfere at the three stages of cancer. Cocoa has been demonstrated to counteract oxidative stress and to have a potential capacity to interact with multiple carcinogenic pathways involved in inflammation, proliferation and apoptosis of initiated and malignant cells. Therefore, restriction of oxidative stress and/or prevention or delayed progression of cancer stages by cocoa antioxidant compounds has gained interest as an effective approach in colorectal cancer prevention. In this review, we look over different in vitro and in vivo studies that have identified potential targets and mechanisms whereby cocoa and their flavonoids could interfere with colonic cancer. In addition, evidence from human studies is also illustrated. Several studies included in this review were supported by Grant AGL2010-17579. This work was also supported by Grant AGL2014-58205-REDC from the Spanish Ministry of Science and Innovation (MICINN). We acknowledge support by the CSIC Open Access Publication Initiative through its Unit of Information Resources for Research (URICI). Peer reviewed 2016-08-25T06:49:25Z 2016-08-25T06:49:25Z 2016-01-21 artículo http://purl.org/coar/resource_type/c_6501 Diseases 4(1): 6 (2016) 2079-9721 http://hdl.handle.net/10261/135866 10.3390/diseases4010006 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100003339 28933386 en #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2014-58205-REDC Publisher's versión https://doi.org/10.3390/diseases4010006 Sí open Multidisciplinary Digital Publishing Institute |
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Cocoa flavonoids Colon cancer In vitro and in vivo studies Molecular mechanism Cocoa flavonoids Colon cancer In vitro and in vivo studies Molecular mechanism Martín, M. Ángeles Goya, Luis Ramos, Sonia Preventive effects of cocoa and cocoa antioxidants in colon cancer |
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Colorectal cancer is one of the main causes of cancer-related mortality in the developed world. Carcinogenesis is a multistage process conventionally defined by the initiation, promotion and progression stages. Natural polyphenolic compounds can act as highly effective antioxidant and chemo-preventive agents able to interfere at the three stages of cancer. Cocoa has been demonstrated to counteract oxidative stress and to have a potential capacity to interact with multiple carcinogenic pathways involved in inflammation, proliferation and apoptosis of initiated and malignant cells. Therefore, restriction of oxidative stress and/or prevention or delayed progression of cancer stages by cocoa antioxidant compounds has gained interest as an effective approach in colorectal cancer prevention. In this review, we look over different in vitro and in vivo studies that have identified potential targets and mechanisms whereby cocoa and their flavonoids could interfere with colonic cancer. In addition, evidence from human studies is also illustrated. |
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Ministerio de Ciencia e Innovación (España) |
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Ministerio de Ciencia e Innovación (España) Martín, M. Ángeles Goya, Luis Ramos, Sonia |
format |
artículo |
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Cocoa flavonoids Colon cancer In vitro and in vivo studies Molecular mechanism |
author |
Martín, M. Ángeles Goya, Luis Ramos, Sonia |
author_sort |
Martín, M. Ángeles |
title |
Preventive effects of cocoa and cocoa antioxidants in colon cancer |
title_short |
Preventive effects of cocoa and cocoa antioxidants in colon cancer |
title_full |
Preventive effects of cocoa and cocoa antioxidants in colon cancer |
title_fullStr |
Preventive effects of cocoa and cocoa antioxidants in colon cancer |
title_full_unstemmed |
Preventive effects of cocoa and cocoa antioxidants in colon cancer |
title_sort |
preventive effects of cocoa and cocoa antioxidants in colon cancer |
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Multidisciplinary Digital Publishing Institute |
publishDate |
2016-01-21 |
url |
http://hdl.handle.net/10261/135866 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100003339 |
work_keys_str_mv |
AT martinmangeles preventiveeffectsofcocoaandcocoaantioxidantsincoloncancer AT goyaluis preventiveeffectsofcocoaandcocoaantioxidantsincoloncancer AT ramossonia preventiveeffectsofcocoaandcocoaantioxidantsincoloncancer |
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