Application of a low transition temperature mixture for the dispersive liquid–liquid microextraction of illicit drugs from urine samples
© 2021 by the authors.
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Multidisciplinary Digital Publishing Institute
2021
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| Subjects: | Low transition temperature mixtures, Deep eutectic solvents, Dispersive liquid–liquid microextraction, Drugs, High performance liquid chromatography, Illicit drugs, Urine, Biological samples, |
| Online Access: | http://hdl.handle.net/10261/266200 http://dx.doi.org/10.13039/501100004271 |
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dig-cide-es-10261-2662002022-04-05T01:51:46Z Application of a low transition temperature mixture for the dispersive liquid–liquid microextraction of illicit drugs from urine samples Gallo, Valeria Tomai, Pierpaolo Lisio, Valerio Di Bosco, Chiara Dal D’Angelo, Paola Fanali, Chiara D’Orazio, Giovanni Silvestro, Ilaria Picó, Yolanda Gentili, Alessandra Sapienza Università di Roma Low transition temperature mixtures Deep eutectic solvents Dispersive liquid–liquid microextraction Drugs High performance liquid chromatography Illicit drugs Urine Biological samples © 2021 by the authors. The use of psychoactive substances is a serious problem in today’s society and reliable methods of analysis are necessary to confirm their occurrence in biological matrices. In this work, a green sample preparation technique prior to HPLC-MS analysis was successfully applied to the extraction of 14 illicit drugs from urine samples. The isolation procedure was a dispersive liquid–liquid microextraction based on the use of a low transition temperature mixture (LTTM), composed of choline chloride and sesamol in a molar ratio 1:3 as the extracting solvent. This mixture was classified as LTTM after a thorough investigation carried out by FTIR and DSC, which recorded a glass transition temperature at −71 °C. The extraction procedure was optimized and validated according to the main Food and Drug Administration (FDA) guidelines for bioanalytical methods, obtaining good figures of merit for all parameters: the estimated lower limit of quantitation (LLOQ) values were between 0.01 µg L−1 (bk-MMBDB) and 0.37 µg L−1 (PMA); recoveries, evaluated at very low spike levels (in the ng-µg L−1 range), spanned from 55% (MBDB) to 100% (bk-MMBDB and MDPV); finally, both within-run and between-run precisions were lower than 20% (LLOQ) and 15% (10xLLOQ). This research was funded by “Sapienza University”, research project “Low transitions temperature mixtures as microextraction solvents”, grant number RG11916B6451D44A. 2022-04-04T11:50:12Z 2022-04-04T11:50:12Z 2021 2022-04-04T11:50:13Z artículo http://purl.org/coar/resource_type/c_6501 Molecules 26(17): 5222 (2021) http://hdl.handle.net/10261/266200 10.3390/molecules26175222 1420-3049 http://dx.doi.org/10.13039/501100004271 Publisher's version http://dx.doi.org/10.3390/molecules26175222 Sí open Multidisciplinary Digital Publishing Institute |
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Low transition temperature mixtures Deep eutectic solvents Dispersive liquid–liquid microextraction Drugs High performance liquid chromatography Illicit drugs Urine Biological samples Low transition temperature mixtures Deep eutectic solvents Dispersive liquid–liquid microextraction Drugs High performance liquid chromatography Illicit drugs Urine Biological samples |
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Low transition temperature mixtures Deep eutectic solvents Dispersive liquid–liquid microextraction Drugs High performance liquid chromatography Illicit drugs Urine Biological samples Low transition temperature mixtures Deep eutectic solvents Dispersive liquid–liquid microextraction Drugs High performance liquid chromatography Illicit drugs Urine Biological samples Gallo, Valeria Tomai, Pierpaolo Lisio, Valerio Di Bosco, Chiara Dal D’Angelo, Paola Fanali, Chiara D’Orazio, Giovanni Silvestro, Ilaria Picó, Yolanda Gentili, Alessandra Application of a low transition temperature mixture for the dispersive liquid–liquid microextraction of illicit drugs from urine samples |
| description |
© 2021 by the authors. |
| author2 |
Sapienza Università di Roma |
| author_facet |
Sapienza Università di Roma Gallo, Valeria Tomai, Pierpaolo Lisio, Valerio Di Bosco, Chiara Dal D’Angelo, Paola Fanali, Chiara D’Orazio, Giovanni Silvestro, Ilaria Picó, Yolanda Gentili, Alessandra |
| format |
artículo |
| topic_facet |
Low transition temperature mixtures Deep eutectic solvents Dispersive liquid–liquid microextraction Drugs High performance liquid chromatography Illicit drugs Urine Biological samples |
| author |
Gallo, Valeria Tomai, Pierpaolo Lisio, Valerio Di Bosco, Chiara Dal D’Angelo, Paola Fanali, Chiara D’Orazio, Giovanni Silvestro, Ilaria Picó, Yolanda Gentili, Alessandra |
| author_sort |
Gallo, Valeria |
| title |
Application of a low transition temperature mixture for the dispersive liquid–liquid microextraction of illicit drugs from urine samples |
| title_short |
Application of a low transition temperature mixture for the dispersive liquid–liquid microextraction of illicit drugs from urine samples |
| title_full |
Application of a low transition temperature mixture for the dispersive liquid–liquid microextraction of illicit drugs from urine samples |
| title_fullStr |
Application of a low transition temperature mixture for the dispersive liquid–liquid microextraction of illicit drugs from urine samples |
| title_full_unstemmed |
Application of a low transition temperature mixture for the dispersive liquid–liquid microextraction of illicit drugs from urine samples |
| title_sort |
application of a low transition temperature mixture for the dispersive liquid–liquid microextraction of illicit drugs from urine samples |
| publisher |
Multidisciplinary Digital Publishing Institute |
| publishDate |
2021 |
| url |
http://hdl.handle.net/10261/266200 http://dx.doi.org/10.13039/501100004271 |
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