Proteome-wide evolutionary analysis reveals lineage-specific adaptations and improves funtional annotation of Schistosoma mansoni proteins.
In this context, comparative proteomic analysis can shed new light on the evolutionary processes that shaped hostparasite interaction over evolutionary time. Taking advantage of the benefits provided by a largescale phylogenetic analysis, in the present work, we reconstructed the evolutionary history of each protein encoded in the S. mansoni genome in comparison with other 12 taxa to gain insights into lineage-specific evolutionary events, potentially related to the parasitic lifestyle, as well as to improve functional annotation. Results The collection of trees reconstructed in this work includes 7,964 phylogenies, which comprises the evolutionary histories of all parasite proteins and their homologs across 12 other organisms. This analysis allowed a deeper understanding of genomic complexity and evolutionary adaptations to a parasitic lifestyle.
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Format: | Anais e Proceedings de eventos biblioteca |
Language: | English eng |
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2013-01-28
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Subjects: | Proteoma., Genoma, Schistosoma Mansoni., Proteome, Genomics., |
Online Access: | http://www.alice.cnptia.embrapa.br/alice/handle/doc/946562 |
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dig-alice-doc-9465622017-08-15T23:37:45Z Proteome-wide evolutionary analysis reveals lineage-specific adaptations and improves funtional annotation of Schistosoma mansoni proteins. SILVA, L. MARCET-HOUBEN, M. NAHUM, L. ZERLOTINI, A. GALBADÓN, T. OLIVEIRA, G. LARISSA SILVA, Centro de Pesquisas René Rachou; MARINA MARCET-HOUBEN, Fiocruz; LAILA NAHUM, Centro de Pesquisas René Rachou; ADHEMAR ZERLOTINI NETO, CNPTIA; TONI GALBADÓN; GUILHERME OLIVEIRA. Proteoma. Genoma Schistosoma Mansoni. Proteome Genomics. In this context, comparative proteomic analysis can shed new light on the evolutionary processes that shaped hostparasite interaction over evolutionary time. Taking advantage of the benefits provided by a largescale phylogenetic analysis, in the present work, we reconstructed the evolutionary history of each protein encoded in the S. mansoni genome in comparison with other 12 taxa to gain insights into lineage-specific evolutionary events, potentially related to the parasitic lifestyle, as well as to improve functional annotation. Results The collection of trees reconstructed in this work includes 7,964 phylogenies, which comprises the evolutionary histories of all parasite proteins and their homologs across 12 other organisms. This analysis allowed a deeper understanding of genomic complexity and evolutionary adaptations to a parasitic lifestyle. X-MEETING 2012. 2013-01-28T11:11:11Z 2013-01-28T11:11:11Z 2013-01-28 2012 2020-01-23T11:11:11Z Anais e Proceedings de eventos In: INTERNATIONAL CONFERENCE OF THE BRAZILIAN ASSOCIATION FOR BIOINFORMATICS AND COMPUTATIONAL BIOLOGY, 8., 2012, Campinas. Abstract book... Ribeirão Preto: AB3C, 2012. http://www.alice.cnptia.embrapa.br/alice/handle/doc/946562 en eng openAccess Não paginado. |
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topic |
Proteoma. Genoma Schistosoma Mansoni. Proteome Genomics. Proteoma. Genoma Schistosoma Mansoni. Proteome Genomics. |
spellingShingle |
Proteoma. Genoma Schistosoma Mansoni. Proteome Genomics. Proteoma. Genoma Schistosoma Mansoni. Proteome Genomics. SILVA, L. MARCET-HOUBEN, M. NAHUM, L. ZERLOTINI, A. GALBADÓN, T. OLIVEIRA, G. Proteome-wide evolutionary analysis reveals lineage-specific adaptations and improves funtional annotation of Schistosoma mansoni proteins. |
description |
In this context, comparative proteomic analysis can shed new light on the evolutionary processes that shaped hostparasite interaction over evolutionary time. Taking advantage of the benefits provided by a largescale phylogenetic analysis, in the present work, we reconstructed the evolutionary history of each protein encoded in the S. mansoni genome in comparison with other 12 taxa to gain insights into lineage-specific evolutionary events, potentially related to the parasitic lifestyle, as well as to improve functional annotation. Results The collection of trees reconstructed in this work includes 7,964 phylogenies, which comprises the evolutionary histories of all parasite proteins and their homologs across 12 other organisms. This analysis allowed a deeper understanding of genomic complexity and evolutionary adaptations to a parasitic lifestyle. |
author2 |
LARISSA SILVA, Centro de Pesquisas René Rachou; MARINA MARCET-HOUBEN, Fiocruz; LAILA NAHUM, Centro de Pesquisas René Rachou; ADHEMAR ZERLOTINI NETO, CNPTIA; TONI GALBADÓN; GUILHERME OLIVEIRA. |
author_facet |
LARISSA SILVA, Centro de Pesquisas René Rachou; MARINA MARCET-HOUBEN, Fiocruz; LAILA NAHUM, Centro de Pesquisas René Rachou; ADHEMAR ZERLOTINI NETO, CNPTIA; TONI GALBADÓN; GUILHERME OLIVEIRA. SILVA, L. MARCET-HOUBEN, M. NAHUM, L. ZERLOTINI, A. GALBADÓN, T. OLIVEIRA, G. |
format |
Anais e Proceedings de eventos |
topic_facet |
Proteoma. Genoma Schistosoma Mansoni. Proteome Genomics. |
author |
SILVA, L. MARCET-HOUBEN, M. NAHUM, L. ZERLOTINI, A. GALBADÓN, T. OLIVEIRA, G. |
author_sort |
SILVA, L. |
title |
Proteome-wide evolutionary analysis reveals lineage-specific adaptations and improves funtional annotation of Schistosoma mansoni proteins. |
title_short |
Proteome-wide evolutionary analysis reveals lineage-specific adaptations and improves funtional annotation of Schistosoma mansoni proteins. |
title_full |
Proteome-wide evolutionary analysis reveals lineage-specific adaptations and improves funtional annotation of Schistosoma mansoni proteins. |
title_fullStr |
Proteome-wide evolutionary analysis reveals lineage-specific adaptations and improves funtional annotation of Schistosoma mansoni proteins. |
title_full_unstemmed |
Proteome-wide evolutionary analysis reveals lineage-specific adaptations and improves funtional annotation of Schistosoma mansoni proteins. |
title_sort |
proteome-wide evolutionary analysis reveals lineage-specific adaptations and improves funtional annotation of schistosoma mansoni proteins. |
publishDate |
2013-01-28 |
url |
http://www.alice.cnptia.embrapa.br/alice/handle/doc/946562 |
work_keys_str_mv |
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