Proteome-wide evolutionary analysis reveals lineage-specific adaptations and improves funtional annotation of Schistosoma mansoni proteins.

In this context, comparative proteomic analysis can shed new light on the evolutionary processes that shaped hostparasite interaction over evolutionary time. Taking advantage of the benefits provided by a largescale phylogenetic analysis, in the present work, we reconstructed the evolutionary histor...

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Main Authors: SILVA, L., MARCET-HOUBEN, M., NAHUM, L., ZERLOTINI, A., GALBADÓN, T., OLIVEIRA, G.
Other Authors: LARISSA SILVA, Centro de Pesquisas René Rachou; MARINA MARCET-HOUBEN, Fiocruz; LAILA NAHUM, Centro de Pesquisas René Rachou; ADHEMAR ZERLOTINI NETO, CNPTIA; TONI GALBADÓN; GUILHERME OLIVEIRA.
Format: Anais e Proceedings de eventos biblioteca
Language:English
eng
Published: 2013-01-28
Subjects:Proteoma., Genoma, Schistosoma Mansoni., Proteome, Genomics.,
Online Access:http://www.alice.cnptia.embrapa.br/alice/handle/doc/946562
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Summary:In this context, comparative proteomic analysis can shed new light on the evolutionary processes that shaped hostparasite interaction over evolutionary time. Taking advantage of the benefits provided by a largescale phylogenetic analysis, in the present work, we reconstructed the evolutionary history of each protein encoded in the S. mansoni genome in comparison with other 12 taxa to gain insights into lineage-specific evolutionary events, potentially related to the parasitic lifestyle, as well as to improve functional annotation. Results The collection of trees reconstructed in this work includes 7,964 phylogenies, which comprises the evolutionary histories of all parasite proteins and their homologs across 12 other organisms. This analysis allowed a deeper understanding of genomic complexity and evolutionary adaptations to a parasitic lifestyle.