Molecular homologous modeling of 3B-HSD2 mutant enzyme: structure-function aspects of Pro222GLN mutation correlates with the experimental data from a patient with congenital adrenal hyperplasia.

Molecular homologous modeling of 3B-HSD2 mutant enzyme: structure-function aspects of Pro222GLN mutation correlates with the experimental data from a patient with congenital adrenal hyperplasia.

Short abstract: We describe the mutation Pro222GIn in HSD3B2 gene on a patient with congenital adrenal hyperplasia. Molecular modeling of 3B-HSD2 mutant allowed us to identify critical role of residue Pro222 on the folding pattern and catalytic activity of the enzyme. The proposed models correlate with the experimental data previously reported.

Enregistré dans:
Détails bibliographiques
Auteurs principaux: FERRAZ, L. F. C., SOARDI, F., FALCÃO, P., NESHICH, G., MELLO, M. P. de
Autres auteurs: LUCIO FABIO CALDAS FERRAZ, CBMEG/Unicamp; FERNANDA SOARDI, CBMEG/Unicamp; PAULA REGINA KUSER FALCAO, CNPTIA; GORAN NESHICH, CNPTIA; MARICILDA PALANDI DE MELLO, CBMEG/Unicamp.
Format: Anais e Proceedings de eventos biblioteca
Langue:Ingles
English
Publié: 2006-08-17
Sujets:Mutação gênica, Hiperplasia adrenal congenital, Modelagem molecular, Biologia molecular, Mutation, Hyperplasia, Molecular Biology,
Accès en ligne:http://www.alice.cnptia.embrapa.br/alice/handle/doc/9296
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Internet

http://www.alice.cnptia.embrapa.br/alice/handle/doc/9296

Documents similaires