Molecular homologous modeling of 3B-HSD2 mutant enzyme: structure-function aspects of Pro222GLN mutation correlates with the experimental data from a patient with congenital adrenal hyperplasia.

Molecular homologous modeling of 3B-HSD2 mutant enzyme: structure-function aspects of Pro222GLN mutation correlates with the experimental data from a patient with congenital adrenal hyperplasia.

Short abstract: We describe the mutation Pro222GIn in HSD3B2 gene on a patient with congenital adrenal hyperplasia. Molecular modeling of 3B-HSD2 mutant allowed us to identify critical role of residue Pro222 on the folding pattern and catalytic activity of the enzyme. The proposed models correlate with the experimental data previously reported.

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Detalles Bibliográficos
Autores principales: FERRAZ, L. F. C., SOARDI, F., FALCÃO, P., NESHICH, G., MELLO, M. P. de
Otros Autores: LUCIO FABIO CALDAS FERRAZ, CBMEG/Unicamp; FERNANDA SOARDI, CBMEG/Unicamp; PAULA REGINA KUSER FALCAO, CNPTIA; GORAN NESHICH, CNPTIA; MARICILDA PALANDI DE MELLO, CBMEG/Unicamp.
Formato: Anais e Proceedings de eventos biblioteca
Idioma:Ingles
English
Publicado: 2006-08-17
Materias:Mutação gênica, Hiperplasia adrenal congenital, Modelagem molecular, Biologia molecular, Mutation, Hyperplasia, Molecular Biology,
Acceso en línea:http://www.alice.cnptia.embrapa.br/alice/handle/doc/9296
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http://www.alice.cnptia.embrapa.br/alice/handle/doc/9296

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