Molecular homologous modeling of 3B-HSD2 mutant enzyme: structure-function aspects of Pro222GLN mutation correlates with the experimental data from a patient with congenital adrenal hyperplasia.

FERRAZ, L. F. C.; SOARDI, F.; FALCÃO, P.; NESHICH, G.; MELLO, M. P. de; LUCIO FABIO CALDAS FERRAZ, CBMEG/Unicamp; FERNANDA SOARDI, CBMEG/Unicamp; PAULA REGINA KUSER FALCAO, CNPTIA; GORAN NESHICH, CNPTIA; MARICILDA PALANDI DE MELLO, CBMEG/Unicamp.

Molecular homologous modeling of 3B-HSD2 mutant enzyme: structure-function aspects of Pro222GLN mutation correlates with the experimental data from a patient with congenital adrenal hyperplasia.

Short abstract: We describe the mutation Pro222GIn in HSD3B2 gene on a patient with congenital adrenal hyperplasia. Molecular modeling of 3B-HSD2 mutant allowed us to identify critical role of residue Pro222 on the folding pattern and catalytic activity of the enzyme. The proposed models correlate with the experimental data previously reported.

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Bibliographic Details
Main Authors:	FERRAZ, L. F. C., SOARDI, F., FALCÃO, P., NESHICH, G., MELLO, M. P. de
Other Authors:	LUCIO FABIO CALDAS FERRAZ, CBMEG/Unicamp; FERNANDA SOARDI, CBMEG/Unicamp; PAULA REGINA KUSER FALCAO, CNPTIA; GORAN NESHICH, CNPTIA; MARICILDA PALANDI DE MELLO, CBMEG/Unicamp.
Format:	Anais e Proceedings de eventos biblioteca
Language:	Ingles English
Published:	2006-08-17
Subjects:	Mutação gênica, Hiperplasia adrenal congenital, Modelagem molecular, Biologia molecular, Mutation, Hyperplasia, Molecular Biology,
Online Access:	http://www.alice.cnptia.embrapa.br/alice/handle/doc/9296
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id	dig-alice-doc-9296
record_format	koha
spelling	dig-alice-doc-92962022-05-17T18:13:39Z Molecular homologous modeling of 3B-HSD2 mutant enzyme: structure-function aspects of Pro222GLN mutation correlates with the experimental data from a patient with congenital adrenal hyperplasia. FERRAZ, L. F. C. SOARDI, F. FALCÃO, P. NESHICH, G. MELLO, M. P. de LUCIO FABIO CALDAS FERRAZ, CBMEG/Unicamp; FERNANDA SOARDI, CBMEG/Unicamp; PAULA REGINA KUSER FALCAO, CNPTIA; GORAN NESHICH, CNPTIA; MARICILDA PALANDI DE MELLO, CBMEG/Unicamp. Mutação gênica Hiperplasia adrenal congenital Modelagem molecular Biologia molecular Mutation Hyperplasia Molecular Biology Short abstract: We describe the mutation Pro222GIn in HSD3B2 gene on a patient with congenital adrenal hyperplasia. Molecular modeling of 3B-HSD2 mutant allowed us to identify critical role of residue Pro222 on the folding pattern and catalytic activity of the enzyme. The proposed models correlate with the experimental data previously reported. ISMB, X-MEETING 2006. Poster D-12. 2022-05-17T18:13:32Z 2022-05-17T18:13:32Z 2006-08-17 2006 Anais e Proceedings de eventos In: ANNUAL INTERNATIONAL CONFERENCE ON INTELLIGENT SYSTEMS FOR MOLECULAR BIOLOGY, 14.; ANNUAL AB3C CONFERENCE, 2., 2006, Fortaleza. Conference Program... Fortaleza: ISCB, 2006. http://www.alice.cnptia.embrapa.br/alice/handle/doc/9296 Ingles en openAccess Não paginado.
institution	EMBRAPA
collection	DSpace
country	Brasil
countrycode	BR
component	Bibliográfico
access	En linea
databasecode	dig-alice
tag	biblioteca
region	America del Sur
libraryname	Sistema de bibliotecas de EMBRAPA
language	Ingles English
topic	Mutação gênica Hiperplasia adrenal congenital Modelagem molecular Biologia molecular Mutation Hyperplasia Molecular Biology Mutação gênica Hiperplasia adrenal congenital Modelagem molecular Biologia molecular Mutation Hyperplasia Molecular Biology
spellingShingle	Mutação gênica Hiperplasia adrenal congenital Modelagem molecular Biologia molecular Mutation Hyperplasia Molecular Biology Mutação gênica Hiperplasia adrenal congenital Modelagem molecular Biologia molecular Mutation Hyperplasia Molecular Biology FERRAZ, L. F. C. SOARDI, F. FALCÃO, P. NESHICH, G. MELLO, M. P. de Molecular homologous modeling of 3B-HSD2 mutant enzyme: structure-function aspects of Pro222GLN mutation correlates with the experimental data from a patient with congenital adrenal hyperplasia.
description	Short abstract: We describe the mutation Pro222GIn in HSD3B2 gene on a patient with congenital adrenal hyperplasia. Molecular modeling of 3B-HSD2 mutant allowed us to identify critical role of residue Pro222 on the folding pattern and catalytic activity of the enzyme. The proposed models correlate with the experimental data previously reported.
author2	LUCIO FABIO CALDAS FERRAZ, CBMEG/Unicamp; FERNANDA SOARDI, CBMEG/Unicamp; PAULA REGINA KUSER FALCAO, CNPTIA; GORAN NESHICH, CNPTIA; MARICILDA PALANDI DE MELLO, CBMEG/Unicamp.
author_facet	LUCIO FABIO CALDAS FERRAZ, CBMEG/Unicamp; FERNANDA SOARDI, CBMEG/Unicamp; PAULA REGINA KUSER FALCAO, CNPTIA; GORAN NESHICH, CNPTIA; MARICILDA PALANDI DE MELLO, CBMEG/Unicamp. FERRAZ, L. F. C. SOARDI, F. FALCÃO, P. NESHICH, G. MELLO, M. P. de
format	Anais e Proceedings de eventos
topic_facet	Mutação gênica Hiperplasia adrenal congenital Modelagem molecular Biologia molecular Mutation Hyperplasia Molecular Biology
author	FERRAZ, L. F. C. SOARDI, F. FALCÃO, P. NESHICH, G. MELLO, M. P. de
author_sort	FERRAZ, L. F. C.
title	Molecular homologous modeling of 3B-HSD2 mutant enzyme: structure-function aspects of Pro222GLN mutation correlates with the experimental data from a patient with congenital adrenal hyperplasia.
title_short	Molecular homologous modeling of 3B-HSD2 mutant enzyme: structure-function aspects of Pro222GLN mutation correlates with the experimental data from a patient with congenital adrenal hyperplasia.
title_full	Molecular homologous modeling of 3B-HSD2 mutant enzyme: structure-function aspects of Pro222GLN mutation correlates with the experimental data from a patient with congenital adrenal hyperplasia.
title_fullStr	Molecular homologous modeling of 3B-HSD2 mutant enzyme: structure-function aspects of Pro222GLN mutation correlates with the experimental data from a patient with congenital adrenal hyperplasia.
title_full_unstemmed	Molecular homologous modeling of 3B-HSD2 mutant enzyme: structure-function aspects of Pro222GLN mutation correlates with the experimental data from a patient with congenital adrenal hyperplasia.
title_sort	molecular homologous modeling of 3b-hsd2 mutant enzyme: structure-function aspects of pro222gln mutation correlates with the experimental data from a patient with congenital adrenal hyperplasia.
publishDate	2006-08-17
url	http://www.alice.cnptia.embrapa.br/alice/handle/doc/9296
work_keys_str_mv	AT ferrazlfc molecularhomologousmodelingof3bhsd2mutantenzymestructurefunctionaspectsofpro222glnmutationcorrelateswiththeexperimentaldatafromapatientwithcongenitaladrenalhyperplasia AT soardif molecularhomologousmodelingof3bhsd2mutantenzymestructurefunctionaspectsofpro222glnmutationcorrelateswiththeexperimentaldatafromapatientwithcongenitaladrenalhyperplasia AT falcaop molecularhomologousmodelingof3bhsd2mutantenzymestructurefunctionaspectsofpro222glnmutationcorrelateswiththeexperimentaldatafromapatientwithcongenitaladrenalhyperplasia AT neshichg molecularhomologousmodelingof3bhsd2mutantenzymestructurefunctionaspectsofpro222glnmutationcorrelateswiththeexperimentaldatafromapatientwithcongenitaladrenalhyperplasia AT mellompde molecularhomologousmodelingof3bhsd2mutantenzymestructurefunctionaspectsofpro222glnmutationcorrelateswiththeexperimentaldatafromapatientwithcongenitaladrenalhyperplasia
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Molecular homologous modeling of 3B-HSD2 mutant enzyme: structure-function aspects of Pro222GLN mutation correlates with the experimental data from a patient with congenital adrenal hyperplasia.

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