Genomic structure and marker-derived gene networks for growth and meat quality traits of Brazilian Nelore beef cattle.

Nelore is the major beef cattle breed in Brazil with more than 130 million heads. Genome-wide association studies (GWAS) are often used to associate markers and genomic regions to growth and meat quality traits that can be used to assist selection programs. An alternative methodology to traditional GWAS that involves the construction of gene network interactions, derived from results of several GWAS is the AWM (Association Weight Matrices)/PCIT (Partial Correlation and Information Theory). With the aim of evaluating the genetic architecture of Brazilian Nelore cattle, we used high-density SNP genotyping data (~770,000 SNP) from 780 Nelore animals comprising 34 half-sibling families derived from highly disseminated and unrelated sires from across Brazil. The AWM/PCIT methodology was employed to evaluate the genes that participate in a series of eight phenotypes related to growth and meat quality obtained from this Nelore sample.

Bibliographic Details

Main Authors:	MUDADU, M. de A., PORTO-NETO, L. R., MOKRY, F. B., TIZIOTO, P. C., OLIVEIRA, P. S. N., TULLIO, R. R., NASSU, R. T., NICIURA, S. C. M., THOLON, P., ALENCAR, M. M. de, HIGA, R. H., ROSA, A. do N., FEIJO, G. L. D., FERRAZ, A. L. J., SILVA, L. O. C. da, MEDEIROS, S. R. de, LANNA, D. P., NASCIMENTO, M. L., CHAVES, A. S., SOUZA, A. R. D. L., PACKER, I. U., TORRES JUNIOR, R. A. de A., SIQUEIRA, F., MOURÃO, G. B., COUTINHO, L. L., REVERTER, A., REGITANO, L. C. de A.
Other Authors:	MAURICIO DE ALVARENGA MUDADU, CNPTIA; LAERCIO R. PORTO-NETO, Commonwealth Scientific and Industrial Research Organization - Agriculture; FABIANA B. MOKRY, UFSCar; POLYANA C. TIZIOTO, UFSCar; PRISCILA S. N. OLIVEIRA, UFSCar; RYMER RAMIZ TULLIO, CPPSE; RENATA TIEKO NASSU, CPPSE; SIMONE CRISTINA MEO NICIURA, CPPSE; PATRICIA THOLON, CPPSE; MAURICIO MELLO DE ALENCAR, CPPSE; ROBERTO HIROSHI HIGA, CNPTIA; ANTONIO DO NASCIMENTO FERREIRA ROSA, CNPGC; GELSON LUIS DIAS FEIJO, CNPGC; ANDRÉ L. J. FERRAZ, UEMS; LUIZ OTAVIO CAMPOS DA SILVA, CNPGC; SERGIO RAPOSO DE MEDEIROS, CNPGC; DANTE P. LANNA, USP; MICHELE L. NASCIMENTO, USP; AMÁLIA S. CHAVES, USP; ANDREA R. D. L. SOUZA, UFMS; IRINEU U. PACKER, USP; ROBERTO AUGUSTO DE A TORRES JUNIOR, CNPGC; FABIANE SIQUEIRA, CNPGC; GERSON B. MOURÃO, USP; LUIZ L. COUTINHO, USP; ANTONIO REVERTER, Commonwealth Scientific and Industrial Research Organization - Agriculture; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE.
Format:	Artigo de periódico biblioteca
Language:	English eng
Published:	2017-01-04
Subjects:	Genome-wide association studies, Association Weight Matrices, Partial Correlation and Information Theory, Gene, Genética, Gado Nelore, Gado de corte, Genótipo, Genotyping, Genotype, Nellore, Beef cattle, Genetic resources,
Online Access:	http://www.alice.cnptia.embrapa.br/alice/handle/doc/1059898
Tags:	Add Tag No Tags, Be the first to tag this record!