Genome-wide association for growth traits in Canchim beef cattle.
Abstract. Studies are being conducted on the applicability of genomic data to improve the accuracy of the selection process in livestock, and genome-wide association studies (GWAS) provide valuable information to enhance the understanding on the genetics of complex traits. The aim of this study was to identify genomic regions and genes that play roles in birth weight (BW), weaning weight adjusted for 210 days of age (WW), and long-yearling weight adjusted for 420 days of age (LYW) in Canchim cattle. GWAS were performed by means of the Generalized Quasi-Likelihood Score (GQLS) method using genotypes from the BovineHD BeadChip and estimated breeding values for BW, WW, and LYW. Data consisted of 285 animals from the Canchim breed and 114 from the MA genetic group (derived from crossings between Charolais sires and 1/2 Canchim + 1/2 Zebu dams). After applying a false discovery rate correction at a 10% significance level, a total of 4, 12, and 10 SNPs were significantly associated with BW, WW, and LYW, respectively. These SNPs were surveyed to their corresponding genes or to surrounding genes within a distance of 250 kb. The genes DPP6 (dipeptidyl-peptidase 6) and CLEC3B (C-type lectin domain family 3 member B) were highlighted, considering its functions on the development of the brain and skeletal system, respectively. The GQLS method identified regions on chromosome associated with birth weight, weaning weight, and long-yearling weight in Canchim and MA animals. New candidate regions for body weight traits were detected and some of them have interesting biological functions, of which most have not been previously reported. The observation of QTL reports for body weight traits, covering areas surrounding the genes (SNPs) herein identified provides more evidence for these associations. Future studies targeting these areas could provide further knowledge to uncover the genetic architecture underlying growth traits in Canchim cattle.
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Language: | English eng |
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2014-12-22
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Subjects: | Gado de corte, Beef cattle, genome-wide association study., |
Online Access: | http://www.alice.cnptia.embrapa.br/alice/handle/doc/1003481 |
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dig-alice-doc-10034812017-08-16T01:39:34Z Genome-wide association for growth traits in Canchim beef cattle. BUZANSKAS, M. E. GROSSI, D. A. VENTURA, R. V. SCHENKEL, F. S. SARGOLZAEI, M. MEIRELLES, S. L. C. MOKRY, F. B. HIGA, R. H. MUDADU, M. A. SILVA, M. V. G. B. NICIURA, S. C. M. TORRES JÚNIOR, R. A. de A. ALENCAR, M. M. REGITANO, L. C. A. MUNARI, D. P. MARCOS E. BUZANSKAS, FCAV/Unesp; DANIELA A. GROSSI, University of Guelph; RICARDO V. VENTURA, University of Guelph; FLÁVIO S. SCHENKEL, University of Guelph; MEHDI SARGOLZAEI, University of Guelph; SARAH L. C. MEIRELLES, Ufla; FABIANA B. MOKRY, UFSCar; ROBERTO HIROSHI HIGA, CNPTIA; MAURICIO DE ALVARENGA MUDADU, CPPSE; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; SIMONE CRISTINA MEO NICIURA, CPPSE; ROBERTO AUGUSTO DE A TORRES JUNIOR, CNPGC; MAURICIO MELLO DE ALENCAR, CPPSE; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; DANÍSIO P. MUNARI, FCAV/Unesp. Gado de corte Beef cattle genome-wide association study. Abstract. Studies are being conducted on the applicability of genomic data to improve the accuracy of the selection process in livestock, and genome-wide association studies (GWAS) provide valuable information to enhance the understanding on the genetics of complex traits. The aim of this study was to identify genomic regions and genes that play roles in birth weight (BW), weaning weight adjusted for 210 days of age (WW), and long-yearling weight adjusted for 420 days of age (LYW) in Canchim cattle. GWAS were performed by means of the Generalized Quasi-Likelihood Score (GQLS) method using genotypes from the BovineHD BeadChip and estimated breeding values for BW, WW, and LYW. Data consisted of 285 animals from the Canchim breed and 114 from the MA genetic group (derived from crossings between Charolais sires and 1/2 Canchim + 1/2 Zebu dams). After applying a false discovery rate correction at a 10% significance level, a total of 4, 12, and 10 SNPs were significantly associated with BW, WW, and LYW, respectively. These SNPs were surveyed to their corresponding genes or to surrounding genes within a distance of 250 kb. The genes DPP6 (dipeptidyl-peptidase 6) and CLEC3B (C-type lectin domain family 3 member B) were highlighted, considering its functions on the development of the brain and skeletal system, respectively. The GQLS method identified regions on chromosome associated with birth weight, weaning weight, and long-yearling weight in Canchim and MA animals. New candidate regions for body weight traits were detected and some of them have interesting biological functions, of which most have not been previously reported. The observation of QTL reports for body weight traits, covering areas surrounding the genes (SNPs) herein identified provides more evidence for these associations. Future studies targeting these areas could provide further knowledge to uncover the genetic architecture underlying growth traits in Canchim cattle. 2014-12-22T11:11:11Z 2014-12-22T11:11:11Z 2014-12-22 2014 2014-12-22T11:11:11Z Artigo de periódico Plos One, San Francisco, v. 9, n. 4, p. 1-8, Apr. 2014 http://www.alice.cnptia.embrapa.br/alice/handle/doc/1003481 10.1371/journal.pone.0094802 en eng openAccess |
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Gado de corte Beef cattle genome-wide association study. Gado de corte Beef cattle genome-wide association study. |
spellingShingle |
Gado de corte Beef cattle genome-wide association study. Gado de corte Beef cattle genome-wide association study. BUZANSKAS, M. E. GROSSI, D. A. VENTURA, R. V. SCHENKEL, F. S. SARGOLZAEI, M. MEIRELLES, S. L. C. MOKRY, F. B. HIGA, R. H. MUDADU, M. A. SILVA, M. V. G. B. NICIURA, S. C. M. TORRES JÚNIOR, R. A. de A. ALENCAR, M. M. REGITANO, L. C. A. MUNARI, D. P. Genome-wide association for growth traits in Canchim beef cattle. |
description |
Abstract. Studies are being conducted on the applicability of genomic data to improve the accuracy of the selection process in livestock, and genome-wide association studies (GWAS) provide valuable information to enhance the understanding on the genetics of complex traits. The aim of this study was to identify genomic regions and genes that play roles in birth weight (BW), weaning weight adjusted for 210 days of age (WW), and long-yearling weight adjusted for 420 days of age (LYW) in Canchim cattle. GWAS were performed by means of the Generalized Quasi-Likelihood Score (GQLS) method using genotypes from the BovineHD BeadChip and estimated breeding values for BW, WW, and LYW. Data consisted of 285 animals from the Canchim breed and 114 from the MA genetic group (derived from crossings between Charolais sires and 1/2 Canchim + 1/2 Zebu dams). After applying a false discovery rate correction at a 10% significance level, a total of 4, 12, and 10 SNPs were significantly associated with BW, WW, and LYW, respectively. These SNPs were surveyed to their corresponding genes or to surrounding genes within a distance of 250 kb. The genes DPP6 (dipeptidyl-peptidase 6) and CLEC3B (C-type lectin domain family 3 member B) were highlighted, considering its functions on the development of the brain and skeletal system, respectively. The GQLS method identified regions on chromosome associated with birth weight, weaning weight, and long-yearling weight in Canchim and MA animals. New candidate regions for body weight traits were detected and some of them have interesting biological functions, of which most have not been previously reported. The observation of QTL reports for body weight traits, covering areas surrounding the genes (SNPs) herein identified provides more evidence for these associations. Future studies targeting these areas could provide further knowledge to uncover the genetic architecture underlying growth traits in Canchim cattle. |
author2 |
MARCOS E. BUZANSKAS, FCAV/Unesp; DANIELA A. GROSSI, University of Guelph; RICARDO V. VENTURA, University of Guelph; FLÁVIO S. SCHENKEL, University of Guelph; MEHDI SARGOLZAEI, University of Guelph; SARAH L. C. MEIRELLES, Ufla; FABIANA B. MOKRY, UFSCar; ROBERTO HIROSHI HIGA, CNPTIA; MAURICIO DE ALVARENGA MUDADU, CPPSE; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; SIMONE CRISTINA MEO NICIURA, CPPSE; ROBERTO AUGUSTO DE A TORRES JUNIOR, CNPGC; MAURICIO MELLO DE ALENCAR, CPPSE; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; DANÍSIO P. MUNARI, FCAV/Unesp. |
author_facet |
MARCOS E. BUZANSKAS, FCAV/Unesp; DANIELA A. GROSSI, University of Guelph; RICARDO V. VENTURA, University of Guelph; FLÁVIO S. SCHENKEL, University of Guelph; MEHDI SARGOLZAEI, University of Guelph; SARAH L. C. MEIRELLES, Ufla; FABIANA B. MOKRY, UFSCar; ROBERTO HIROSHI HIGA, CNPTIA; MAURICIO DE ALVARENGA MUDADU, CPPSE; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; SIMONE CRISTINA MEO NICIURA, CPPSE; ROBERTO AUGUSTO DE A TORRES JUNIOR, CNPGC; MAURICIO MELLO DE ALENCAR, CPPSE; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; DANÍSIO P. MUNARI, FCAV/Unesp. BUZANSKAS, M. E. GROSSI, D. A. VENTURA, R. V. SCHENKEL, F. S. SARGOLZAEI, M. MEIRELLES, S. L. C. MOKRY, F. B. HIGA, R. H. MUDADU, M. A. SILVA, M. V. G. B. NICIURA, S. C. M. TORRES JÚNIOR, R. A. de A. ALENCAR, M. M. REGITANO, L. C. A. MUNARI, D. P. |
format |
Artigo de periódico |
topic_facet |
Gado de corte Beef cattle genome-wide association study. |
author |
BUZANSKAS, M. E. GROSSI, D. A. VENTURA, R. V. SCHENKEL, F. S. SARGOLZAEI, M. MEIRELLES, S. L. C. MOKRY, F. B. HIGA, R. H. MUDADU, M. A. SILVA, M. V. G. B. NICIURA, S. C. M. TORRES JÚNIOR, R. A. de A. ALENCAR, M. M. REGITANO, L. C. A. MUNARI, D. P. |
author_sort |
BUZANSKAS, M. E. |
title |
Genome-wide association for growth traits in Canchim beef cattle. |
title_short |
Genome-wide association for growth traits in Canchim beef cattle. |
title_full |
Genome-wide association for growth traits in Canchim beef cattle. |
title_fullStr |
Genome-wide association for growth traits in Canchim beef cattle. |
title_full_unstemmed |
Genome-wide association for growth traits in Canchim beef cattle. |
title_sort |
genome-wide association for growth traits in canchim beef cattle. |
publishDate |
2014-12-22 |
url |
http://www.alice.cnptia.embrapa.br/alice/handle/doc/1003481 |
work_keys_str_mv |
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